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| Date | Location | Result | |
| 2/19/22 | Saint Paul, MN | Macalester 79, St. Scholastica 66 | Box score |
| 2/16/22 | Duluth, MN (Reif Gym) | St. Olaf 91, St. Scholastica 74 | Box score |
| 2/14/22 | Duluth, MN (Reif Gym) | St. Scholastica 69, Concordia (MN) 67 | Box score |
| 2/12/22 | Saint Peter, MN | Gustavus Adolphus 78, St. Scholastica 67 | Box score |
| 2/9/22 | St. Paul, MN | St. Scholastica 69, Bethel 67 | Box score |
| 2/7/22 | Saint Paul, MN | Macalester 72, St. Scholastica 63 | Box score |
| 2/5/22 | Duluth, MN (Reif Gym) | Carleton 67, St. Scholastica 57 | Box score |
| 2/2/22 | Duluth, MN (Reif Gym) | Hamline 72, St. Scholastica 61 | Box score |
| 1/29/22 | Winona, MN | Saint Mary's 77, St. Scholastica 59 | Box score |
| 1/26/22 | Saint Paul, MN | St. Scholastica 75, Northwestern (MN) 73 | Box score |
| 1/22/22 | Collegeville, MN | Saint John's 83, St. Scholastica 62 | Box score |
| 1/19/22 | Duluth, MN (Reif Gym) | Augsburg 84, St. Scholastica 63 | Box score |
| 1/15/22 | Duluth, MN (Reif Gym) | Gustavus Adolphus 83, St. Scholastica 74 | Box score |
| 1/12/22 | Northfield, MN | St. Olaf 75, St. Scholastica 58 | Box score |
| 1/10/22 | Duluth, MN (Reif Gym) | St. Scholastica 74, Bethel 73 (OT) | Box score |
| 1/8/22 | Moorhead, MN | Concordia (MN) 70, St. Scholastica 62 | Box score |
| 1/5/22 | Saint Paul, MN | Hamline 62, St. Scholastica 56 | Box score |
| 12/30/21 | Dubuque, IA | Bethany Lutheran 81, St. Scholastica 68 | Box score |
| 12/29/21 | Dubuque, IA | Lawrence 78, St. Scholastica 68 | Box score |
| 12/11/21 | Northfield, MN | Carleton 96, St. Scholastica 90 | Box score |
| 12/8/21 | Duluth, MN (Reif Gym) | Macalester 57, St. Scholastica 50 | Box score |
| 12/4/21 | Duluth, MN (Reif Gym) | Saint Mary's 68, St. Scholastica 66 | Box score |
| 12/1/21 | Minneapolis, MN | Augsburg 83, St. Scholastica 68 | Box score |
| 11/20/21 | Duluth, MN (Reif Gym) | Saint John's 74, St. Scholastica 51 | Box score |
| 11/17/21 | Duluth, MN (Reif Gym) | St. Scholastica 69, UW-Superior 60 | Box score |
| 11/10/21 | Duluth, MN (Reif Gym) | UW-River Falls 77, St. Scholastica 76 (OT) | Box score |